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sting inhibitor h 151  (MedChemExpress)


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    Structured Review

    MedChemExpress sting inhibitor h 151
    Sting Inhibitor H 151, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 224 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sting+inhibitor+h+151/H-151/pm42121378-39-0-6
    Average 99 stars, based on 224 article reviews
    sting inhibitor h 151 - by Bioz Stars, 2026-09
    99/100 stars

    Images

    Related Articles

    Drug discovery:

    Article Title: Tumor Eradication via UTMC-Induced Thrombotic Infarction Combined with Redox-Responsive Nanoparticle-Mediated Chemo-Immunotherapy.
    Article Snippet: Tumor infarction is a promising treatment strategy that delivers benefits such as short therapeutic duration, low resistance potential, and broad applicability across diverse tumor types.. However, treatments that induce vascular thrombosis cannot secure durable tumor elimination due to relapse caused by residual tumor cells (often localized in the surviving rim).. To address this limitation, we combined tumor infarction therapy with chemotherapy and immunotherapy.

    Inhibition:

    Article Title: Tumor Eradication via UTMC-Induced Thrombotic Infarction Combined with Redox-Responsive Nanoparticle-Mediated Chemo-Immunotherapy.
    Article Snippet: Tumor infarction is a promising treatment strategy that delivers benefits such as short therapeutic duration, low resistance potential, and broad applicability across diverse tumor types.. However, treatments that induce vascular thrombosis cannot secure durable tumor elimination due to relapse caused by residual tumor cells (often localized in the surviving rim).. To address this limitation, we combined tumor infarction therapy with chemotherapy and immunotherapy.

    Activation Assay:

    Article Title: Engineered Salmonella -mediated c-di-AMP delivery activates STING to remodel the tumor microenvironment
    Article Snippet: .. To investigate the STING dependence of SL disA -induced immune activation, co-treatment experiments were performed with the STING inhibitor H-151 (2 μM final concentration; MedChemExpress, USA). ..

    Concentration Assay:

    Article Title: Engineered Salmonella -mediated c-di-AMP delivery activates STING to remodel the tumor microenvironment
    Article Snippet: .. To investigate the STING dependence of SL disA -induced immune activation, co-treatment experiments were performed with the STING inhibitor H-151 (2 μM final concentration; MedChemExpress, USA). ..

    Functional Assay:

    Article Title: Toxoplasma gondii GRA3 activates interferon-stimulated genes and STAT6 by the cGAS-STING pathway to promote parasite proliferation.
    Article Snippet: .. To determine whether this regulation requires functional STING, macrophages were pretreated with the STING inhibitor H-151 (1 μM, MCE). ..

    Expressing:

    Article Title: Toxoplasma gondii GRA3 activates interferon-stimulated genes and STAT6 by the cGAS-STING pathway to promote parasite proliferation.
    Article Snippet: .. Our findings revealed that the ME49Δgra3 strain resulted in significantly reduced IFN-β expression and secretion across various macrophages, suggesting that GRA3 may be involved in regulating the cGAS/STING signaling pretreated with the STING inhibitor H-151 (MCE, 1μM) and then infected with ME49wt and ME49Δgra3 strains for 24 hours. ..

    Infection:

    Article Title: Toxoplasma gondii GRA3 activates interferon-stimulated genes and STAT6 by the cGAS-STING pathway to promote parasite proliferation.
    Article Snippet: .. Our findings revealed that the ME49Δgra3 strain resulted in significantly reduced IFN-β expression and secretion across various macrophages, suggesting that GRA3 may be involved in regulating the cGAS/STING signaling pretreated with the STING inhibitor H-151 (MCE, 1μM) and then infected with ME49wt and ME49Δgra3 strains for 24 hours. ..



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    STING loss- and gain- of function studies support a growth-restraining role in PEL. (A) BCBL1 and (B) BC3 cells were treated with 5 µM <t>H151</t> for 72 hours and subjected to CellTiter-Glo assay. Western blot of STING overexpression 48 hours after electroporation of 100 ng pcDNA3.1 (EV) or 50-100 ng STING plasmid in (C) BCBL1 and (D) BC3 cells. CellTiter-Glo assay in (E) BCBL1 and (F) BC3 cells at 72 hours after EV or STING plasmid electroporation. Data is represented as relative luminescence units. Data (A-B, E-F) are presented as mean ± SD. * indicates p<0.05; ** indicates p<0.01; *** indicates p<0.001 by Student’s t-test.
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    Image Search Results


    STING loss- and gain- of function studies support a growth-restraining role in PEL. (A) BCBL1 and (B) BC3 cells were treated with 5 µM H151 for 72 hours and subjected to CellTiter-Glo assay. Western blot of STING overexpression 48 hours after electroporation of 100 ng pcDNA3.1 (EV) or 50-100 ng STING plasmid in (C) BCBL1 and (D) BC3 cells. CellTiter-Glo assay in (E) BCBL1 and (F) BC3 cells at 72 hours after EV or STING plasmid electroporation. Data is represented as relative luminescence units. Data (A-B, E-F) are presented as mean ± SD. * indicates p<0.05; ** indicates p<0.01; *** indicates p<0.001 by Student’s t-test.

    Journal: Frontiers in Immunology

    Article Title: STING inhibits viral lytic reactivation and cell growth in primary effusion lymphoma

    doi: 10.3389/fimmu.2026.1823240

    Figure Lengend Snippet: STING loss- and gain- of function studies support a growth-restraining role in PEL. (A) BCBL1 and (B) BC3 cells were treated with 5 µM H151 for 72 hours and subjected to CellTiter-Glo assay. Western blot of STING overexpression 48 hours after electroporation of 100 ng pcDNA3.1 (EV) or 50-100 ng STING plasmid in (C) BCBL1 and (D) BC3 cells. CellTiter-Glo assay in (E) BCBL1 and (F) BC3 cells at 72 hours after EV or STING plasmid electroporation. Data is represented as relative luminescence units. Data (A-B, E-F) are presented as mean ± SD. * indicates p<0.05; ** indicates p<0.01; *** indicates p<0.001 by Student’s t-test.

    Article Snippet: BCBL1 and BC3 cells were treated with 5 μM STING inhibitor H151 (MedChemExpress cat# Hy-112693) ( ) prepared in DMSO for 72 hours prior to CellTiter-Glo assay.

    Techniques: Glo Assay, Western Blot, Over Expression, Electroporation, Plasmid Preparation